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Moro blood orange extract supports weight loss

Article-Moro blood orange extract supports weight loss

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Supplementation with Moro blood orange standardized extract across a 6-month intervention revealed a significant change in body mass and body composition compared to placebo.

Since 1975, the global prevalence of obesity has almost tripled with 39% of adults over 18 years old being classified as overweight and 13% as obese.1 Recent studies have shown that many polyphenolic compounds, including anthocyanins which are present in citrus fruit, have positive effects on health and weight management.2-6 

Native to Sicily and cultivated at the feet of the Etna volcano, the Moro orange cultivar Citrus sinensis Osbeck (Rutaceae) is the most highly pigmented red orange with high anthocyanin content. 7-9 

In a recent study published in Nutrients (DOI:, researchers investigated the effect of Moro orange cultivar extract on weight loss and all safety markers of liver toxicity. This single-site, double-blind, randomized clinical trial investigated supplementation across a six-month intervention period in Brisbane, Australia.  

The 98 participants who completed the study were overweight (BMI 25-35kg/m2) but otherwise healthy adults aged 20 to 65 years old. The standard extract called Morosil® was provided by Bionap S.R.L. The supplement was in capsules, each containing 400mg of standardized extract to be taken with water after breakfast. The placebo product was maltodextrin which was stored within a matching capsule and administered in the same way as the extract.  

Participants were randomly allocated to a control group taking the placebo or an intervention group supplementing with the Moro orange standardized extract. Participants’ dietary intake, body measurements, blood parameters, and body composition were assessed during enrollment. Participants were also asked to complete 30 minutes of walking 3 times per week as well as follow a kilojoule-controlled diet.  

The participants attended the study site 1, 2, 3, 4 and 5 months after their baseline for more body measures, dietary intake, and tolerance assessments. A final assessment identical to the one taken at baseline was completed during month 6 (the final month). 

Study findings 

After supplementing for six months, both participant groups experience significant improvements in body weight, BMI, and waist and hip circumferences; however, the active group lost more weight than the placebo. Additionally, the intervention group showed a significant decrease in BMI, fat mass, visceral fat, abdominal fat, and waist and hip circumference at 6-months in the intervention group compared to placebo. Overall, the Moro blood orange standardized extract combined with diet and exercise was shown to be safe and well-tolerated. The researchers conclude that “supplementation with the standardized extract may significantly contribute as a complementary strategy in weight management programs.” 




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