Healthy Ageing: Powered by Ubiquinol

The importance of Kaneka Ubiquinol^TM for healthy ageing

It is estimated that the average cell uses 10 billion ATP a day,¹ which equates to 40kg of ATP being used by the body each day.² Of that, the mitochondria produce approximately 90% of the biochemical energy that cells need to survive.³

Ubiquinol is critical to mitochondrial function, and is essential for the health of all human tissues and organs.⁴ Ubiquinol is also essential to maintaining overall health, impacting cardiovascular and cognitive health, menopause, fertility, energy and fatigue, mitochondrial health, and healthy ageing.

Ubiquinol is unique in that it is the only endogenously synthesised lipid-soluble antioxidant in human cells. Due to its redox property, Ubiquinol also has a free-radical-scavenging effect and serves as a powerful antioxidant.⁵ Ubiquinol protects membrane phospholipids from peroxidation as well as mitochondrial DNA and membrane proteins from free-radical-induced oxidative damage, thus providing protection against cellular damage and a higher risk of cell death.^6,7 Ubiquinol also participates in the regeneration of other antioxidants, such as vitamins C and E.⁸

Depletion of Ubiquinol has a significant impact systemically on metabolic regulation, brain function, immunity, and regulation of inflammatory pathways, linking it to the pathogenesis of a range of disorders.^9-15

What are mitochondria?

Mitochondria are complex organelles, hundreds to thousands of which are found in all cells in the body. These organelles, via the Kreb’s cycle (cellular respiration), produce adenosine triphosphate (ATP) – the energy currency of a cell – inside the mitochondria. And as part of the electron transport chain (ETC) in the mitochondrial membrane, Ubiquinol facilitates the production of this energy.

Mitochondria also play a vital role in cellular processes such as calcium storage, iron homeostasis, production of hormones and neurotransmitters, regulation of apoptosis, and modulation of immune responses.^{8, 16}

Impacts on Ubiquinol production

The production of Ubiquinol declines with age and prolonged stress (due to lifestyle, diet or environmental factors), as does the ability to convert ubiquinone to Ubiquinol within the body.^{8, 17-20} Endogenous Ubiquinol production starts to decrease after the age of 20 and, by  80 years, the myocardial concentration of Ubiquinol has reduced by around half.^20-22

This impaired production and conversion is believed to contribute to age-related declines in cellular energy production and function, as well as increased oxidative damage with reduced antioxidant protection.²³

Consumers can support their natural Ubiquinol levels through supplementation. Studies have shown that Ubiquinol supplements are effective in a range of conditions.^24-34

60-62

Market opportunities with Kaneka Ubiquinol™

• Ubiquinol (the active form of CoQ10) has higher bioavailability^35-38 and is 8 times more absorbable^39-46 than ubiquinone (the oxidised form of CoQ10).
• Research supports the therapeutic health benefits of supplementation with Kaneka Ubiquinol™.
• Ubiquinol is present naturally in the human body, and supplementation with the stable, chemically-identical Kaneka Ubiquinol™ is well tolerated:^47-49

• There have been no reports of significant adverse side-effects of oral supplementation at doses as high as 3000 mg/day for up to 8 months, 1200 mg/day for up to 16 months and 600 mg/day for up to 30 months.

• According to the observed safe level (OSL) risk assessment method, evidence of safety is strong with doses up to 1200 mg/day of Ubiquinol.
• Kaneka Ubiquinol™ was the recipient of the Annual Ingredient Cardiovascular Health Award 2024 by Functional Foods for Wellness Summit (FFWS), and is a finalist in the Healthy Ageing category of the NutraIngredients-Asia Awards for 2024.

ABOUT KANEKA UBIQUINOL™

Kaneka Corporation is the sole global supplier of Kaneka Ubiquinol™, the potent antioxidant, produced via a unique patented yeast fermentation using meticulous Japanese manufacturing processes. Supported by 80+ patents, 45+ years of research, and 100+ scientific studies for cardiovascular health, fertility support, energy production, and mitochondrial health, Kaneka Ubiquinol™ is the active form of CoQ10 that comprises more than 96% of the total CoQ10 (ubiquinone and Ubiquinol) in human plasma.

Kaneka’s impeccable standards are built on the Japanese philosophy of ‘Kaizen’ meaning ‘a commitment to quality and efficiency, and the pursuit of perfection – from the company’s rigorous commitment to quality and research, through to its outstanding stakeholder support.

Email: [email protected]

Website: www.ubiquinol.net.au

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