In the botanicals world, Andrographis paniculata has been known and in use for centuries in Ayurveda and Traditional Chinese Medicine. This ancient weedy shrub native to India and Southern Asia has become a best-selling cold remedies in several countries.
Alongside its immune health benefits, Andrographis also promotes a healthy and regular digestive system. Multiple studies on Andrographis find that the botanical supports healthy levels of immune cells in the blood and reduces levels of inflammatory mediators, giving rise to its popularity in the immune health category. Belonging to the Acanthaceae family, Andrographis has been used in treatment applications for viral fever, chicken pox, eczema, epidemic encephalitis B, hepatitis, pneumonia, ulcers, neurodermatitis and respiratory infections. The greatest uptake of Andrographis in traditional medicine is in India, China, Pakistan, Bangladesh, Malaysia, Philippines, Indonesia and Thailand—where it’s also been used to treat insect and snake bites.
Andrographolide, a bicyclic diterpenoid lactone, is the major active compound that has various tested pharmacological effects such as anti-inflammatory, cardioprotective and immunoregulatory activity.
Natural Remedies, an India-based research-driven herbal healthcare company, has conducted extensive research on Andrographis, which has since led to the discovery of their standardised extract, KalmCold, or AP-Bio. In a randomised, double-blind placebo-controlled clinical trial, Kalmcold/AP-Bio was effective in reducing the symptoms of upper respiratory tract infection. The assessment involved quantification of symptom scores by the Visual Analogue Scale. Nine self-evaluated symptoms of cough, expectoration, nasal discharge, headache, fever, sore throat, earache, malaise, fatigue, and sleep disturbance were scored. A total of 223 patients of both genders were randomised into two groups, which received either KalmCold (at a dosage of 200 mg/day) or placebo in a double-blind manner. In both the treatments, mean scores of all symptoms showed a decreasing trend from day one to day three. Furthermore, from day three to day five, most of the symptoms in the placebo-treated group either remained unchanged or grew aggravated, whereas in the KalmCold treated group, all symptoms showed a decreasing trend.
In another study, a standardised extract of Andrographis reduced the cold symptom severity of 158 adults with cold. Participants given 1,200 mg daily of Andrographis experienced significant improvements by the second day of treatment and improved further by day four, compared with participants who received a placebo.
In light of available scientific evidence and traditional usage, Andrographis is a proven solution for immunity support. Could it this botanical's turn in the spotlight?